The Race for a Vaccine. The Road to Demaskus

I hear they’d to dump a load of vaccines above in Louth

Easy come easy go

Have they ever ate something that was supposed to be in the fridge but was in the boot of the car for 6 hours. Be grand. The sniff test is enough

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By god, where would we be without big pharma

Here we go

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And these are the lads we are told we need to genuflect to as “the experts”

“A number of vials”.

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HSE killing it as usual

Pint pints pints

Anyone want to post that up?

Israel’s Early Vaccine Data Offers Hope

Initial studies show a significant drop in infections and hospitalizations after just one dose, and very few cases after two. Experts caution that the results are preliminary.

A man receiving the second dose of Covid-19 vaccine in Tel Aviv. Israel has outstripped the rest of the world in vaccinating its population, making it an international test case.

A man receiving the second dose of Covid-19 vaccine in Tel Aviv. Israel has outstripped the rest of the world in vaccinating its population, making it an international test case.Credit…Oded Balilty/Associated Press

Isabel Kershner

By Isabel Kershner

  • Jan. 25, 2021

JERUSALEM — Israel, which leads the world in vaccinating its population against the coronavirus, has produced some encouraging news: Early results show a significant drop in infection after just one shot of a two-dose vaccine, and better than expected results after both doses.

Public health experts caution that the data, based on the Pfizer-BioNTech vaccine, is preliminary and has not been subjected to clinical trials. Even so, Dr. Anat Ekka Zohar, vice president of Maccabi Health Services, one of the Israeli health maintenance organizations that released the data, called it “very encouraging.”

In the first early report, Clalit, Israel’s largest health fund, compared 200,000 people aged 60 or over who received a first dose of the vaccine to a matched group of 200,000 who had not been vaccinated yet. It said that 14 to 18 days after their shots, the partially vaccinated patients were 33 percent less likely to be infected.

At about the same time, Maccabi’s research arm said it had found an even larger drop in infections after just one dose: a decrease of about 60 percent, 13 to 21 days after the first shot, in the first 430,000 people to receive it.

Maccabi did not specify an age group or whether it had compared the data with a matched, non-vaccinated cohort.

ImagePeople lining up to receive coronavirus vaccines in Jerusalem. Early data shows significant drops in infection after just one dose.

People lining up to receive coronavirus vaccines in Jerusalem. Early data shows significant drops in infection after just one dose.Credit…Menahem Kahana/Agence France-Presse — Getty Images

On Monday, the Israeli Health Ministry and Maccabi released new data on people who had received both doses of the vaccine, showing extremely high rates of effectiveness.

The ministry found that out of 428,000 Israelis who had received their second doses, a week later only 63, or 0.014 percent, had contracted the virus. Similarly, the Maccabi data showed that more than a week after having received the second dose, only 20 out of roughly 128,600 people, about 0.01 percent, had contracted the virus.

In clinical trials the Pfizer vaccine proved 95 percent effective after two doses in preventing coronavirus infection in people without evidence of previous infection. The Israeli results, if they hold up, suggest the efficacy could be even higher, though rigorous comparisons to unvaccinated people have not yet been published.

“This is very encouraging data,” Dr. Zohar said. “We will monitor these patients closely in order to examine if they continue to suffer from mild symptoms only and do not develop complications as a result of the virus.”

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Both Clalit and Maccabi warned that their findings were preliminary and said they would soon be followed by more in-depth statistical analysis in peer-reviewed scientific publications.

Israel, where more than 40 percent of the population has already received a first dose of the vaccine, has become something of an international test case for vaccination efficacy.

With its small population, highly digitized universal health system, and rapid, military-assisted vaccine rollout, Israel’s real-world data provides a useful supplement to clinical trials for researchers, pharmaceutical companies and policymakers.

Israel made a deal with Pfizer in which the drug company ensured the country an early and steady supply of vaccines in exchange for data. The Health Ministry has made public a redacted version of the agreement.

Despite its race to vaccinate, Israel is suffering a devastating third wave of the coronavirus. The government reimposed a strict national lockdown this month after weeks of soaring infections and deaths.

Israel was set to halt most air travel in and out of the country starting at midnight on Monday in an effort to block the arrival of emerging virus variants that could threaten the country’s vaccination campaign. Two vaccine makers said Monday that their vaccines were slightly less effective against one of the new variants.

Image

The deserted departure hall at Ben Gurion International Airport on Monday. Israel remains under a strict lockdown and was set to halt most air travel in and out of the country starting at midnight on Monday.

The deserted departure hall at Ben Gurion International Airport on Monday. Israel remains under a strict lockdown and was set to halt most air travel in and out of the country starting at midnight on Monday.Credit…Abir Sultan/EPA, via Shutterstock

While real-world data like that from Israel is useful, it is subject to variables that can skew the results and which clinical trials try to account for.

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Covid-19 Vaccines ›

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Answers to Your Vaccine Questions

If I live in the U.S., when can I get the vaccine?

While the exact order of vaccine recipients may vary by state, most will likely put medical workers and residents of long-term care facilities first. If you want to understand how this decision is getting made, this article will help.

When can I return to normal life after being vaccinated?

If I’ve been vaccinated, do I still need to wear a mask?

Will it hurt? What are the side effects?

Will mRNA vaccines change my genes?

The early Israeli numbers are based on the first people to get the vaccine. Such people, experts say, are likely to be more concerned or informed about the virus and therefore more careful about social distancing and mask wearing. They could also differ from those who did not rush to get the shot by location and socio-economic status.

Also, experts say, the disease changes over time. Prof. Ran Balicer, the chief innovation officer at Clalit and a leading Israeli epidemiologist, said that two-week-old data can be like evidence from a different era or “about a million vaccines ago in Israeli terms.”

Maccabi said that it would release more data weekly. “The main message,” Maccabi said in a statement, is that even the first dose of the vaccine “is effective and reduces morbidity and lowers hospitalizations by many tens of percent.”

A hazard of releasing raw data, experts cautioned, is that it can be misinterpreted.

After Clalit first publicized its early numbers two weeks ago, many people heard about a 33 percent drop in cases, not the expected 95 percent, and jumped to the erroneous conclusion that the Pfizer shot didn’t work.

There was an uproar in Britain, where the authorities have delayed giving the second dose by up to 12 weeks, as opposed to the 21-day gap on which Pfizer based its trials.

Professor Balicer thought of the results as good news and was dismayed at how they were interpreted.

“We were reassured enough to tell everyone that we were seeing what we were supposed to be seeing right after Day 14,” he said. “I don’t know how it turned into a message of ‘Oh my God, it doesn’t work.’”

A health worker administering a dose of the Pfizer-BioNtech coronavirus vaccine last week at a stadium in Netanya, Israel.Credit…Jack Guez/Agence France-Presse — Getty Images

Professor Balicer, who is also the chairman of the team of experts advising the Israeli government on its Covid-19 response, hoped the positive results might have a bearing on an imminent government decision regarding a third lockdown.

“Covid has turned us all into amateur scientists,” said Talya Miron-Shatz, an associate professor and expert in medical decision-making at Ono Academic College in central Israel. “We are all looking at data, but most people are not scientists.”

Israel, which began vaccinating people on Dec. 20, has given a first shot to more than 2.6 million Israelis and both shots to more than a million people.

After starting with people aged 60 and above, health care workers and others at high risk, Israel is now offering vaccines to people over 40 and to high school students aged 16 to 18 to allow them to get back to school. The military is assisting the effort and 700 army reserve medics are helping at vaccination centers.

Prof. Jonathan Halevy, the president of Shaare Zedek Medical Center in Jerusalem, had not studied the findings of the H.M.O.s but said that two weeks after the first dose was rolled out he began seeing a drop in severe cases.

“I know several people who became infected close to the time they got the vaccine, but they got it lightly,” he said.

Still, Israel remains under a national lockdown and officials are concerned about the emergence of new, highly contagious variants. It remains to be seen how effective the vaccines are against the new variants.

Despite what appears to be the early success of the vaccine, the virus continues to wreak havoc in Israel. Professor Halevy said his hospital’s Covid wards were still packed to capacity and he expected that it would take another two or three weeks to see a decline.

The virus has killed more than 1,000 Israelis so far this month alone, nearly a quarter of those who have died from the pandemic virus overall.

Health officials and experts have attributed much of the recent increase in infection to the fast-spreading variant first detected in Britain.

People waiting in their cars for coronavirus tests this month in Tel Aviv.Credit…Ammar Awad/Reuters

Israel, the Virus and the Vaccine


As Virus Grows Stealthier, Vaccine Makers Reconsider Battle Plans
Jan. 25, 2021


After Quick Vaccine Success, Israel Faces New Virus Woes
Jan. 6, 2021


The Palestinian Authority approves the use of Russia’s Sputnik V vaccine.
Jan. 11, 2021

Isabel Kershner, a correspondent in Jerusalem, has been reporting on Israeli and Palestinian politics since 1990. She is the author of “Barrier: The Seam of the Israeli-Palestinian Conflict.” @IKershner •

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Getting sick of these Bernie memes.

No need for mittens in Tel Aviv

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Genocide Ted says no to masks, apparently…maybe someone could watch the video and report

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The experts don’t know about masks now.

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They must have sold all the over stocked items.
They’ll mandate 3d glasses next…after cornering the market of course

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They have been reading TFK and learned that masks may not be as protective as they believed and people with masks are still getting infected.

Masks are worth fuck all…unless you’re a building merchant from county Clare and a mate of a td

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