That’s damning
Absolutely no conclusive evidence there that increased viral load has any more impact.
Now in future, if you are claiming that something is medically or scientifically proven please use medical or scientific journals as opposed to newspapers.
It could just as easily be that these people have undetected underlying conditions.
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Really?
Do you consider The Lancet to be a reputable journal?
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(20)30232-2/fulltext
Coronavirus disease 2019 (COVID-19) is a new pandemic disease. We previously reported that the viral load of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) peaks within the first week of disease onset.
,
Findings from Feb, 2020, indicated that the clinical spectrum of this disease can be very heterogeneous.
Here, we report the viral RNA shedding patterns observed in patients with mild and severe COVID-19.
76 patients admitted to the First Affiliated Hospital of Nanchang University (Nanchang, China) from Jan 21 to Feb 4, 2020, were included in the study. All patients were confirmed to have COVID-19 at the time of admission by RT-PCR. The viral loads of their nasopharyngeal swab samples were estimated with the DCt method (Ctsample – Ctref). Patients who had any of the following features at the time of, or after, admission were classified as severe cases: (1) respiratory distress (≥30 breaths per min); (2) oxygen saturation at rest ≤93%; (3) ratio of partial pressure of arterial oxygen to fractional concentration of oxygen inspired air ≤300 mm Hg; or (4) severe disease complications (eg, respiratory failure, requirement of mechanical ventilation, septic shock, or non-respiratory organ failure). 46 (61%) individuals were classified as mild cases and 30 (39%) were classified as severe cases. The basic demographic data and initial clinical symptoms of these patients are shown in the appendix. Parameters did not differ significantly between the groups, except that patients in the severe group were significantly older than those in the mild group, as expected.
No patient died from the infection. 23 (77%) of 30 severe cases received intensive care unit (ICU) treatment, whereas none of the mild cases required ICU treatment.
• View related content for this article
We noted that the DCt values of severe cases were significantly lower than those of mild cases at the time of admission (appendix). Nasopharyngeal swabs from both the left and right nasal cavities of the same patient were kept in a sample collection tube containing 3 mL of standard viral transport medium. All samples were collected according to WHO guidelines.
The mean viral load of severe cases was around 60 times higher than that of mild cases, suggesting that higher viral loads might be associated with severe clinical outcomes. We further stratified these data according to the day of disease onset at the time of sampling. The DCt values of severe cases remained significantly lower for the first 12 days after onset than those of corresponding mild cases (figure A). We also studied serial samples from 21 mild and ten severe cases (figure B). Mild cases were found to have an early viral clearance, with 90% of these patients repeatedly testing negative on RT-PCR by day 10 post-onset. By contrast, all severe cases still tested positive at or beyond day 10 post-onset. Overall, our data indicate that, similar to SARS in 2002–03,
patients with severe COVID-19 tend to have a high viral load and a long virus-shedding period. This finding suggests that the viral load of SARS-CoV-2 might be a useful marker for assessing disease severity and prognosis.
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Scratch that NYC has updated its figures, just as dismal as before.
Not proven, but like the rabid dog that you are you will keep going.
As the balanced NS article posted up in its entirety above suggests, there are conflicting theories but as yet nothing substantial. And as for any data coming out of Chi-na at the minute, you would want your head examined depending on it but then again maybe you do!
You picked an argument which you made personal. You made claims which you couldn’t back up.
You got clamped royally.
Suck it up, mate.
For instance, health workers investigating the covid-19 outbreak in the Lombardy region of Italy looked at more than 5,000 infected people and found no difference in viral load between those with symptoms and those without. They reached this conclusion after tracing people who had been in contact with someone known to be infected with the coronavirus and testing them to see if they were also infected.
Similarly, when doctors at the Guangzhou Eighth People’s Hospital in China took repeated throat swabs from 94 covid-19 patients, starting on the day they became ill and finishing when they cleared the virus, they found no obvious difference in viral load between milder cases and those who developed more severe symptoms
I didn’t say that study didn’t exist.
Whereas you claimed the study I quoted didn’t exist - you said there was no evidence that viral load made a difference to the severity of symptoms.
There is.
That’s the difference.
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Upon reflection, you did indeed say inconclusive, which is indeed correct. Apologies.
Sound
I think what we can say conclusively is the more you are around this virus, the more likely it is to grab onto you. The amount of virus in hospital wards full of intubated patients must be off the charts.
DZ, I will agree with you that Trump is an idiot, that he said it’s a hoax, that he ignores the medics and the science . . . and that he is the worst possible leader that America could have at have at this time . . . and maybe the leaders of the Netherlands, Belgium, Switzerland, and Luxembourg might all be nice guys and believers in Science and listen to their health officials . . . . however, that still does not ignore the fact that the number of deaths per head of population in those European countries are significantly higher than in the US, with all of them in the 30s and the Netherlands now up to 45 deaths per million . . . The number of total cases in the US per one million of population is in fact lower than Ireland and the number of deaths per million is exactly the same (7) . . . I just think that for a lot of people their visceral dislike of Trump (and for some their visceral dislike of the Yanks in general) blinds them to the actual stats . . . what the heck is going on the with the Dutch, the Swiss, and the Belgians?
Imperial College’s reputation will take a battering from all this flip-flopping
I think governments should be judged on how prepared they were for a pandemic and how they responded to it once it started to impact them. We can get the former out of the way quickly, nobody was well prepared, some countries better prepared than others. This is a good resource to look at how well prepared individual countries are, the US and UK are ranked #1 and #2.
As for response, it’s far too early to draw any conclusions, we will know better once we get to the peak and things start to level out and hopefully decline. What we can say is Italy was totally overwhelmed, and Spain not far behind. I think more than anything else this is a test of how set up hospitals are to deal with infectious diseases, and how much ICU capacity they have, the US has 2X to 3X ICU bed capacity to the EU average. It will all be needed I think, and more.
The mathematical modelers have got a chasing from the virus.
what do you make of those ccp scumabgs sending cheap shitty defective medical gear to countries at the moment? looking to get a soft power advantage and kudos. The Russians are all over Italy at the same craic, taking advantage of people at their lowest
This is a test to see how set up hospitals are?